UI Customization - possible to disable a menu option based on path?

System

I think I know the answer to this, but am tossing it out there in case there's a chance it can be done without a whole lot of recoding default UI behavior.

I'd like to be able to disable the File->Rename menu option if the user is within a certain path in the workarea. If the user is not within that specific path, the File->Rename should be available to use again.

Possible with the basic UI Customization tools they give us? I don't want to recode the Rename operation. Just change the behavior of the menu option.

I'm a dreamer...