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ERROR: Unable to do hand shake with the sender

Just adding to the collective knowledge (cuz I couldn't find anything about it on support.interwoven.com):

If you see the error message "ERROR: Unable to do hand shake with the sender" in the OD log files on your target machine, you should check to see if you were a monkey and put the "-inst instance" argument in the right order.

If you have iwodstart -k k=v -inst instance you'll see the above error.

Make sure you use iwodstart -inst instance -k k=v in the correct order.

Although, and this is being kinda a stickler, the IW documentation at the back of the 5.0.1 OD admin guide lists the API for the command line tool as:

iwodstart -h | -v [od_home deployment [-sim] [-inst instance -k "key=value"]] [-async]

Maybe I just don't know how to read that, but I interpret that to mean that for every -k argument you pass, you would also have a -inst flag. Anyway, FYI: you don't. I have a single -inst flag to identify my deployment and 6 -k key/value pairs.