Email from web server causes Error: -2147024893

System

Error -2147024893 : The system cannot find the path specified.

Our MediaBin web Client has been working great. Totally out of the blue, we are getting this error. I figure it's something with our smtp configuration however, I can't seem to find any information on it. What exactly is the mediabin code doing and what does this error mean?

FYI - The file is prepared to be sent on the transfer folder share.
FYI - The folder has read/write permissions for Everyone

To help troubleshoot the issue, we setup an email from the relay server and it worked. I also initiated an email from a seperate sql server and it worked too. To me, this says that the mail server and smtp relay server are both not the problem.

I rebooted the web server and also the MediaBin Server with no luck.